A Japanese man, who was 61 years of age, presented with multiple neuri
lemmoma in both legs which had arisen from different levels of both sc
iatic nerves. There were no clinical findings relating to von Reckling
hausen's disease in the patient or his siblings. Multiple neurilemmoma
may be the result of embryonic metameric anomalies. The condition may
be distinguished from von Recklinghausen's disease by the distributio
n of the lesions and genetic analysis.