M. Nakakura et al., EFFECT OF IONTOPHORETIC PATTERNS ON IN-VIVO ANTIDIURETIC RESPONSE TO DESMOPRESSIN ACETATE ADMINISTERED TRANSDERMALLY, Journal of drug targeting., 2(6), 1995, pp. 487-492
The effects of concentration, amperage and duration on the antidiureti
c response induced by iontophoretic delivery of desmopressin acetate (
DDAVP) were examined using a diabetes insipidus model in rats. A highe
r current density brought about a larger and longer antidiuretic respo
nse. Prolonged iontophoretic duration caused an overdose. Repeated sho
rt iontophoretic treatments with lower current density maintained a co
nstant response with a short lag time and a rapid disappearance of pha
rmacological response immediately after cessation of the final treatme
nt. This type of iontophoresis substantially reduced the inter-subject
variability of response as compared to the response using an intranas
al route of administration.