PYRIDOXINE DEPENDENT EPILEPSY WITH IATROGENIC SENSORY NEURONOPATHY

Authors
MCLACHLAN RS BROWN WF
Citation
Rs. Mclachlan et Wf. Brown, PYRIDOXINE DEPENDENT EPILEPSY WITH IATROGENIC SENSORY NEURONOPATHY, Canadian journal of neurological sciences, 22(1), 1995, pp. 50-51
Citations number
8
Categorie Soggetti
Clinical Neurology
Journal title
Canadian journal of neurological sciences → ACNP
ISSN journal
03171671
Volume
22
Issue
1
Year of publication
1995
Pages
50 - 51
Database
ISI
SICI code
0317-1671(1995)22:1<50:PDEWIS>2.0.ZU;2-8
Abstract
An 18-year-old man was treated from birth with chronic high dose pyrid oxine (vitamin B-6) up to 2000 mg per day for pyridoxine-dependent sei zures. Within two years of onset of treatment, he developed a sensory neuropathy which did not progress over the following 16 years. Electro physiological studies were consistent with a pure sensory neuronopathy expressed as centripetal degeneration of processes of the dorsal root ganglion cells.