PROPHYLAXIS OF VENOUS THROMBOEMBOLISM IN BRAIN-TUMOR PATIENTS

Thromboembolism is a common problem in patients with brain tumors. Wit hin this population are subpopulations of patients at varying but subs tantial risk for deep vein thrombosis and pulmonary embolism. Prophyla ctic strategies can be applied to these various risk groups that will dramatically reduce the incidence of thromboembolism, and these should be applied on a routine basis. The standard prophylactic methods for thromboembolic prophylaxis include mechanical devices (e.g., graduated leg stockings; external pneumatic calf compression) and pharmacologic al agents (e.g., low dose heparin). In addition, a basic knowledge of low molecular weight heparins and heparinoids is essential because the se new agents have a potentially promising role in the prophylaxis of neurological disease in certain patients. The principles concerning th e prophylaxis of venous thromboembolic disease in patients with brain tumors are addressed in this review.