ABSOLUTE-CONFIGURATION OF CURACIN-A, A NOVEL ANTIMITOTIC AGENT FROM THE TROPICAL MARINE CYANOBACTERIUM LYNGBYA-MAJUSCULA

Authors
NAGLE DG GERALDS RS YOO HD GERWICK WH KIM TS NAMBU M WHITE JD
Citation
Dg. Nagle et al., ABSOLUTE-CONFIGURATION OF CURACIN-A, A NOVEL ANTIMITOTIC AGENT FROM THE TROPICAL MARINE CYANOBACTERIUM LYNGBYA-MAJUSCULA, Tetrahedron letters, 36(8), 1995, pp. 1189-1192
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
8
Year of publication
1995
Pages
1189 - 1192
Database
ISI
SICI code
0040-4039(1995)36:8<1189:AOCANA>2.0.ZU;2-A
Abstract
Curacin A is a structurally novel antimitotic agent isolated from the Caribbean cyanobacterium Lyngbya majuscula. Its planar structure has b een previously determined from a spectroscopic investigation. Here, we define the complete relative and absolute configuration of curacin A by comparison of products obtained from chemical degradation of the na tural product with the same substances prepared by synthesis. Curacin A is shown to have 2R, 13R, 19R, 21S absolute configuration.