THE SYNTHESIS AND CONFORMATION OF DIHYDROXY-CYCLO(D-PRO-L-PRO-D-PRO-L-PRO)

Authors
GILBERTSON SR PAWLICK RV
Citation
Sr. Gilbertson et Rv. Pawlick, THE SYNTHESIS AND CONFORMATION OF DIHYDROXY-CYCLO(D-PRO-L-PRO-D-PRO-L-PRO), Tetrahedron letters, 36(8), 1995, pp. 1229-1232
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
8
Year of publication
1995
Pages
1229 - 1232
Database
ISI
SICI code
0040-4039(1995)36:8<1229:TSACOD>2.0.ZU;2-J
Abstract
The first synthesis of a derivative of cyclo(D-Pro-L-Pro-D-Pro-L-Pro) is reported. The convergent route to the molecule is amenable to the s ynthesis of gram quantities of the desired compound. The cyclization o f the linear tetramer was found to give specifically one conformation of the 12 member macrocycle. The structural assignment, by 2D NMR, of the favored conformation is also reported.