MULTIPLE SOLID-PHASE SYNTHESIS VIA FMOC-AMINO ACID FLUORIDES

Authors
WENSCHUH H BEYERMANN M ROTHEMUND S CARPINO LA BIENERT M
Citation
H. Wenschuh et al., MULTIPLE SOLID-PHASE SYNTHESIS VIA FMOC-AMINO ACID FLUORIDES, Tetrahedron letters, 36(8), 1995, pp. 1247-1250
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
8
Year of publication
1995
Pages
1247 - 1250
Database
ISI
SICI code
0040-4039(1995)36:8<1247:MSSVFA>2.0.ZU;2-2
Abstract
In addition to displaying high reactivity. Fmoc-amino acid fluorides a re shown to be highly soluble and stable for extended periods in organ ic solvents such as DMF and therefore to be recommended for use in Mul tiple Peptide Synthesis. A series of analogs of alamethicin and a part ial sequence (22 amino acids) of the CNG-channel forming protein BOVTE STIS have been assembled with excellent results.