E. Sottofattori et al., SYNTHESIS OF 2-[(3-AMINOALKYL OR 3-BROMOALKYL)AMINO]-4H-1-BENZOPYRAN-4-ONE DERIVATIVES, Tetrahedron letters, 36(8), 1995, pp. 1331-1332
The title compounds were advantageously synthesized from 2-(dialkylami
no)chromones and 1,3-diaminopropane (or 1-amino-3-bromopropane) by ami
ne exchange. The 3-cyano derivatives 5 were directly prepared from 2-(
dimethylamino)chromones 1 and KCN by nitro displacement.