2 INDEPENDENT SYNTHESES OF (2S,4S)[5,5-H-2(2)]-5,5'-DIHYDROXYLEUCINE AND (2S,4R)[5,5-H-2(2)]-5,5'-DIHYDROXYLEUCINE

Authors
DURAND X HUDHOMME P KHAN JA YOUNG DW
Citation
X. Durand et al., 2 INDEPENDENT SYNTHESES OF (2S,4S)[5,5-H-2(2)]-5,5'-DIHYDROXYLEUCINE AND (2S,4R)[5,5-H-2(2)]-5,5'-DIHYDROXYLEUCINE, Tetrahedron letters, 36(8), 1995, pp. 1351-1354
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
8
Year of publication
1995
Pages
1351 - 1354
Database
ISI
SICI code
0040-4039(1995)36:8<1351:2ISO(A>2.0.ZU;2-H
Abstract
Two independent stereoselective syntheses have been used to prepare sa mples of (2S,4S)-[5, 5-H-2(2)]-5,5'-dihydroxyleucine (3b) and the (2S, 4R)-diastereoisomer (3a). The first synthesis uses (2S)-pyroglutamic a cid as starring material and provides the (2S,4S)-isomer (3b), while t he second starts with (2S,4R)-4-hydroxyproline and provides the (2S,4R )-isomer (3a).