ENANTIOSELECTIVE MICHAEL-MUKAIYAMA ADDITIONS OF SILYLKETENE ACETALS TO 2-CARBOXYCYCLOPENTENONES PROMOTED BY CHIRAL TI COMPLEXES

Authors
BERNARDI A KARAMFILOVA K BOSCHIN G SCOLASTICO C
Citation
A. Bernardi et al., ENANTIOSELECTIVE MICHAEL-MUKAIYAMA ADDITIONS OF SILYLKETENE ACETALS TO 2-CARBOXYCYCLOPENTENONES PROMOTED BY CHIRAL TI COMPLEXES, Tetrahedron letters, 36(8), 1995, pp. 1363-1364
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
8
Year of publication
1995
Pages
1363 - 1364
Database
ISI
SICI code
0040-4039(1995)36:8<1363:EMAOSA>2.0.ZU;2-E
Abstract
The conjugate addition of t-butylpropionate silylketeneacetal 2 to 2-c arboxycyclopentenones 3a-b promoted by TADDOL-derived Ti chlorides giv es the ketoacid 6 with excellent d.e. and e.e. up to 47%.