DENDRITIC CELLS AS INITIATORS OF TUMOR IMMUNE-RESPONSES - A POSSIBLE STRATEGY FOR TUMOR-IMMUNOTHERAPY

Since all T-cell-mediated immune responses require antigen presentatio n, antigen-presenting cells (APCs) may be of central importance for th e generation and regulation of tumor immunity. This article describes approaches used to induce tumor immunity via modulation of the present ation of tumor antigen, either by tumor-antigen-exposed dendritic cell s or by tumor cells engineered to act as APCs.