Ea. Hoffman et al., MATCHING PULMONARY STRUCTURE AND PERFUSION VIA COMBINED DYNAMIC MULTISLICE CT AND THIN-SLICE HIGH-RESOLUTION CT, Computerized medical imaging and graphics, 19(1), 1995, pp. 101-112
Taking advantage of two scan modes of an electron beam CT scanner (Ima
tron), we have developed a method utilizing x-ray CT for relating pulm
onary perfusion to global and regional anatomy. A high temporal resolu
tion mode, used to follow bolus contrast agent, is combined with a hig
h spatial resolution mode to obtain the structure-function fusion. A s
oftware module has been developed for our image analysis package (VIDA
)(R) to automatically calculate physiologic parameters of flow and int
egrate these color coded functional measurements into a corresponding
high spatial resolution data set. We present the scanning methodology
details and give examples from our physiologic based research to demon
strate strengths of combining dynamic and high resolution CT to unique
ly characterize pulmonary normal and pathophysiology.