K. Yamaoka et al., CHANGES IN SPECIFIC AMINO-ACID-RESIDUES AND NA-ATPASE ACTIVITY IN CELL-MEMBRANES OF RAT CEREBRAL-CORTEX BY LOW-DOSE X-IRRADIATION(,K+), Physiological chemistry and physics and medical NMR, 26(4), 1994, pp. 323-328
Citations number
21
Categorie Soggetti
Biophysics,Biology,Physiology,"Radiology,Nuclear Medicine & Medical Imaging
This study examines the influence of low dose X-irradiation on the str
ucture and transport function of cell membranes of rat cerebral cortex
. We found that unlike high dose irradiation which promotes membrane d
amage, low dose irradiation stimulates the SH group of membrane protei
ns and enhances the ability to control the membrane transport mechanis
m as reflected by an increase in Na+, K+-ATPase activity. The concentr
ation of cysteine (Cys) significantly increased at 25-100 cGy and the
concentration of cystine (Cys-Cys) significantly decreased at 25 cGy.
It showed no dose dependent changes in tyrosine (Tyr), phenylalanine (
Phe) and glycine (Gly). Similarly phospholipid and cholesterol levels
were unchanged. Na+, K+-ATPase activities significantly decreased at 1
00 cGy or higher but significantly increased at doses of 25 and 50 cGy
.