RENAL-FAILURE IN A PATIENT WITH CHRONIC LYMPHOCYTIC-LEUKEMIA TREATED WITH FLUDARABINE

Authors
MACHETA MP PARAPIA LA GOULDESBROUGH DR
Citation
Mp. Macheta et al., RENAL-FAILURE IN A PATIENT WITH CHRONIC LYMPHOCYTIC-LEUKEMIA TREATED WITH FLUDARABINE, Journal of Clinical Pathology, 48(2), 1995, pp. 181-182
Citations number
9
Categorie Soggetti
Pathology
Journal title
Journal of Clinical Pathology → ACNP
ISSN journal
00219746
Volume
48
Issue
2
Year of publication
1995
Pages
181 - 182
Database
ISI
SICI code
0021-9746(1995)48:2<181:RIAPWC>2.0.ZU;2-7
Abstract
The case history of a man with refractory chronic lymphocytic leukaemi a who developed acute renal failure following treatment with fludarabi ne is presented. A renal biopsy specimen showed features of mesangioca pillary glomerulonephritis, a rare occurrence in chronic lymphocytic l eukaemia. The rapid cytocidal action of fludarabine may result in the development of renal glomerular lesions when used to treat a well diff erentiated B cell malignancy.