CONTRACTILE FAILURE IN EARLY MYOCARDIAL-ISCHEMIA - MODELS AND MECHANISMS

In early myocardial ischemia we find a number of salient electrical an d ionic alterations. This article reviews action potential shortening, K accumulation, and contractile failure. Enhanced K efflux during ear ly myocardial ischemia has been attributed to a number of mechanisms, including: the inhibition of active K uptake, osmotic changes, efflux of K ions linked to anion extrusion, cation exchange, altered cellular energy levels, in particular, the opening of ATP-dependent K channels , the involvement of other ion channels, a H/K-ion exchanger, and a ca techolamine-dependent pathway, The different mechanisms are discussed. Action potential shortening was described as a salient characteristic of myocardial ischemia in 1954 by Trautwein and Dudel, and was attrib uted to enhanced outward current. Recently it has been shown by severa l authors that ATP-dependent potassium channels play a key role in thi s context. Contractile failure in early myocardial ischemia has been e xplained by shortening of the action potential duration, reduced cytop lasmic free calcium levels, intracellular acidification, and a rise in inorganic phosphate and Rig. In summary, it is concluded that ATP-dep endent K channels may be involved in each of these three phenomena.