THE EFFECT OF PROPOFOL ON NORMAL AND INCREASED PULMONARY VASCULAR-RESISTANCE IN ISOLATED-PERFUSED RABBIT LUNG

The effects of propofol and its intralipid vehicle on increased and no rmal pulmonary vascular resistances (PVR) were studied in an in situ p erfused rabbit lung model which controlled all major determinants of P VR. Propofol at both 5 and 10 mu g/mL significantly reduced PVR increa ses by the thromboxane mimetic, U46619. In contrast, similar volumes o f intralipid further increased PVR. Neither propofol nor intralipid ha d any effect on normal PVR. We conclude that propofol at 5 and 10 mu g /mL is able to reduce increased PVR but has no effect on normal PVR.