PURE PARACETAMOL FOR DIRECT COMPRESSION .2. STUDY OF THE PHYSICOCHEMICAL AND MECHANICAL-PROPERTIES OF SINTERED-LIKE CRYSTALS OF PARACETAMOL

Part I described the production of sintered-like Paracetamol crystals. In this second part, the physicochemical and technological behaviour of these crystals is investigated. The wettability and dissolution pro perties are then studied. The crystals exhibit a polyhedric habit whic h induces good flow properties. The porous crystal structure, resultin g from the arrangement of the microcrystallites inside the crystalline particle, greatly improves compression ability, probably because of i ncreased plasticity. Moreover, their porous crystal structure induces fast dissolution. Tablets were prepared by direct compression from a m ixture of FGH Paracetamol with the usual excipients. These tablets dis integrate instantaneously and Paracetamol dissolution is complete with in 10 min.