MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II AND C4 ALLELES IN MEXICAN-AMERICANS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS

Citation
Jd. Reveille et al., MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II AND C4 ALLELES IN MEXICAN-AMERICANS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS, Tissue antigens, 45(2), 1995, pp. 91-97
Citations number
30
Categorie Soggetti
Immunology,"Cell Biology
Journal title
ISSN journal
00012815
Volume
45
Issue
2
Year of publication
1995
Pages
91 - 97
Database
ISI
SICI code
0001-2815(1995)45:2<91:MHCCAC>2.0.ZU;2-F
Abstract
Few data exist on associations of class II and class III alleles of th e major histocompatibility complex (MHC) and susceptibility to systemi c lupus erythematosus (SLE) in Mexican Americans, a group of predomina ntly mixed Spanish and Native American ancestry. Therefore, MHC class II alleles (HLA-DRB1, DQA1, DQB1, DPA1 and DPB1 alleles) and C4 alloty pes were determined in 52 Mexican American SLE patients and 105 ethnic -matched controls. HLA-DRB10301 and C4A* Q0 were each increased in th e SLE patients, especially HLA-DRB10301 in those with anti-Ro/SSA aut oantibodies. C4AQ0 was associated with HLA-DRB1*0301 only in a minori ty of patients and controls. Anti-U1-RNP antibodies were significantly associated with the presence of HLA-DQB10302, and the risk for the p roduction of anti-Re antibodies was heightened by the presence of at l east three (out of four possible) DQA1 chains possessing a glutamine a t position 34 and/or DQB1 chains a leucine at position 26 of their out ermost domains. Thus the HLA class II and C4 null allele associations that have been noted in other ethnic groups are also found in Mexican Americans, suggesting shared susceptibility factors across ethnic line s in predisposition to SLE.