VIRAL ONCOPROTEIN BINDING TO PRB, P107, P130, AND P300

The purpose of this review is to bring attention to some additional wo rk in the tumor virus/tumor suppressor field which may have been overs hadowed by reports describing adenovirus, SV40, and HPV oncoprotein bi nding to pRB and p53. The data reviewed herein provide further support for the model that a common mechanism by which DNA tumor viruses tran sform cells involves inactivation of cellular proteins which function as negative regulators of cell growth.