ADENOVIRUS PROTEINS THAT REGULATE SUSCEPTIBILITY TO TNF ALSO REGULATETHE ACTIVITY OF PLA(2)

Expression of the adenovirus E1A protein induces susceptibility to TNF . To counteract this effect, the adenovirus encodes a number of gene p roducts that preserve host cell resistance to TNF. The E1B-19K protein , the E3 14.7 K protein, and the E3 10.4/14.5 K dimer each function in different cell types to provide resistance to TNF. Expression of E1A also results in the activation of PLA(2) and the release of arachidoni c acid from the dying cell. The E3 14.7 K protein can prevent the acti vation of PLA(2), suggesting that in addition to providing host cell r esistance to TNF, this protein also functions in an anti-inflammatory manner.