THE NOVEL GABA-A RECEPTOR-LIGAND NNC-14-0764 - L)-2,3-DIHYDRODIIMIDAZO[1,5-A-1',2'-C]-QUINAZOLINE

The crystal and molecular structure of the title compound, C17H14N6O, has been determined. The two molecules in the asymmetric unit have ver y similar geometrical features, the major difference being in the over all convex or concave shape of the molecular surface. As a consequence , although as expected, the cyclopropyl rings are approximately perpen dicular to the general molecular plane; the three C atoms of the cyclo propyl groups are distributed quite differently above and below the ge neral molecular plane in the two molecules. Consequences of this effec t for theoretical consideration of drug activity are discussed.