AMPLIFICATION OF RESPONSES TO SUMATRIPTAN BY VARIOUS AGONISTS IN RABBIT ISOLATED ILIAC ARTERY

Authors
YILDIZ O TUNCER M
Citation
O. Yildiz et M. Tuncer, AMPLIFICATION OF RESPONSES TO SUMATRIPTAN BY VARIOUS AGONISTS IN RABBIT ISOLATED ILIAC ARTERY, Journal of cardiovascular pharmacology, 25(3), 1995, pp. 508-510
Citations number
17
Categorie Soggetti
Cardiac & Cardiovascular System","Respiratory System","Pharmacology & Pharmacy
Journal title
Journal of cardiovascular pharmacology → ACNP
ISSN journal
01602446
Volume
25
Issue
3
Year of publication
1995
Pages
508 - 510
Database
ISI
SICI code
0160-2446(1995)25:3<508:AORTSB>2.0.ZU;2-P
Abstract
Rabbit iliac arteries (IA) were almost unresponsive to the serotonin ( 5-HT1-like) receptor agonist sumatriptan under control conditions, whe reas this agent elicited concentration-dependent contractions in IA ri ngs given a moderate tone by threshold concentrations (EC(10)-EC(20)) of prostaglandin F-2 alpha(PGF(2 alpha)), angiotensin II (AII), histam ine, norepinephrine (NE), phenylephrine (PE), or potassium chloride. T hese results suggest that 5-HT1-like receptors are uncovered not only by histamine or thromboxane/prostaglandin receptor agonists, as shown in rabbit renal and femoral arteries, but also by various agonists in rabbit IA as shown in this study.