M. Laposata et al., FATTY-ACID ETHYL-ESTERS - NONOXIDATIVE METABOLITES OF ETHANOL, Prostaglandins, leukotrienes and essential fatty acids, 52(2-3), 1995, pp. 87-91
Fatty acid ethyl esters are esterification products of fatty acids and
ethanol. These compounds have been detected in the serum and cells of
individuals following ethanol ingestion. Fatty acid ethyl esters can
be quantitated by gas chromatography-mass spectroscopy (CC-MS) in the
serum following ethanol ingestion and have been found in concentration
s up to 42 mu M. Fatty acid ethyl esters have also been isolated from
adipose tissue of subjects ingesting fatty acid ethyl ester capsules a
s well as from subjects ingesting ethanol. HepG2 cells, a human hepato
blastoma cell line, have also been shown to generate fatty acid ethyl
esters when incubated with 1.25 mu M fatty acid and 0.17 M ethanol. Fa
tty acid ethyl esters were found to be toxic to HepG2 cells when prese
nted to the cells in the core of low density lipoprotein particles.