COUPLING THE CHOLESTEROL-SUPPRESSIVE AND TUMOR-SUPPRESSIVE ACTIONS OFPALM-OIL TO THE IMPACT OF ITS MINOR CONSTITUENTS ON 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE-ACTIVITY
Ce. Elson et Aa. Qureshi, COUPLING THE CHOLESTEROL-SUPPRESSIVE AND TUMOR-SUPPRESSIVE ACTIONS OFPALM-OIL TO THE IMPACT OF ITS MINOR CONSTITUENTS ON 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE-ACTIVITY, Prostaglandins, leukotrienes and essential fatty acids, 52(2-3), 1995, pp. 205-208
The impact of palm oil on cardiovascular disease and cancer may be exp
lained by the mevalonate-suppressive action of constituent isoprenoid
end products of plant secondary metabolism. Assorted monoterpenes, ses
quiterpenes, carotenoids and tocotrienols down regulate, post-transcri
ptionally, 3-hydroxy-3-methylglutaryl coenzyme A reductase activity th
ereby modestly decreasing cholesterol synthesis and concomitantly decr
easing LDL cholesterol, The reductase activity in tumor tissues differ
s from that of liver in being resistant to sterol feedback regulation,
Tumor reductase activity retains sensitivity to the post-transcriptio
nal regulation, As a consequence, the isoprenoid-mediated suppression
of mevalonate synthesis depletes tumor tissues of two intermediate pro
ducts, farnesyl pyrophosphate and geranylgeranyl pyrophosphate, which
are incorporated post-translationally into growth control-associated p
roteins.