RELATION BETWEEN CLONINGERS TEMPERAMENTAL DIMENSIONS AND THE TREATMENT RESPONSES OF PATIENTS WITH BIPOLAR AFFECTIVE-DISORDER - DEPRESSIVE PHASE

Relationship between Cloniger's temperamental dimensions and the 41 pa tients with diagnosis ICD10 F31.3-5 responses to tricyclic antidepress ants treatment was investigated using the CGI, HAMD, BPRS, and MADRS v alue changes measured weekly during one month period. An index utilize d as the classification variable, based on regression analysis results where dependent variable was average score of global improvement and independent variables were 11 subscales of Cloninger's Threedimensiona l personality questionnaire, was defined by equation I = 2RD3 (attach able) + NS1 (excitable). On the basis of the index the patients were d ivided into three groups (high, medium, and low index value). Relation between the index and the patients responses to the treatment were st udied using ANOVA with repeated measurements. Statistically significan t differences in the treatment responses pattern were found on global improvement scale, anxiety-depression syndrome, gravity of disease, an d the MADRS total score. The interaction of groups and time of the rem aining scales were in the same direction but not statistically signifi cant. Findings indicated that individuals with higher sensitivity to n oradrenalin and low basic dopaminergic activity might improve during t he first three weeks of hospitalization faster.