COMPARATIVE KINETICS OF 2 ORALLY-ADMINISTERED FLUOROQUINOLONES IN DOG- ENROFLOXACIN VERSUS MARBOFLOXACIN

Plasma disposition of orally administered enrofloxacin and marbofloxac in and their abilities to ensure appropriate plasma concentrations wit h respect to the minimal inhibitory concentrations of the targeted ger ms were compared in dogs (n=8). Oral doses of enrofloxacin and marbofl oxacin were 5 and 2 mg.kg(-1) respectively. As enrofloxacin has a main bacteriologically active metabolite (ciprofloxacin), the comparison w as performed by measuring the plasma concentrations using validated sp ecific HPLC and unspecific microbiological methods. It was shown that the plasma peak concentration was similar for both antibiotic but mar bufloxacin was eliminated more slowly than enrofloxacin permitting eff ective plasma activities to be maintained for longer than enrofloxacin .