MUTATION POSITION AND TYPE OF SUBSTITUTION IN THE BETA-SUBUNIT OF THERNA-POLYMERASE INFLUENCE IN-VITRO ACTIVITY OF RIFAMYCINS IN RIFAMPICIN-RESISTANT MYCOBACTERIUM-TUBERCULOSIS

Authors
BODMER T ZURCHER G IMBODEN P TELENTI A
Citation
T. Bodmer et al., MUTATION POSITION AND TYPE OF SUBSTITUTION IN THE BETA-SUBUNIT OF THERNA-POLYMERASE INFLUENCE IN-VITRO ACTIVITY OF RIFAMYCINS IN RIFAMPICIN-RESISTANT MYCOBACTERIUM-TUBERCULOSIS, Journal of antimicrobial chemotherapy, 35(2), 1995, pp. 345-348
Citations number
10
Categorie Soggetti
Microbiology,"Pharmacology & Pharmacy
Journal title
Journal of antimicrobial chemotherapy → ACNP
ISSN journal
03057453
Volume
35
Issue
2
Year of publication
1995
Pages
345 - 348
Database
ISI
SICI code
0305-7453(1995)35:2<345:MPATOS>2.0.ZU;2-F
Abstract
Quantitative susceptibility testing for rifampicin, rifabutin and rifa pentine of 36 Mycobacterium tuberculosis isolates with known sequences for the gene encoding for the RNA polymerase beta-subunit (rpoB) reve aled that both mutation position and type of amino acid substitution i nfluence the in-vitro activity of rifamycins in rifampicin-resistant s trains.