CD1-TUBE DEFECTS( CELLS IN MOTHERS OF STILLBORN INFANTS WITH NEURAL)

In healthy individuals, CD1+ cells are found in thymic tissue, but not in peripheral blood, The thymus, as a key organ of the neuroendocrine system, frequently shows gross abnormalities in infants with neural t ube defects. In order to study the immunologic significance of fetal t hymic findings, maternal T-lymphocyte subpopulations were investigated , In 10 mothers of healthy newborns, 5 mothers of stillborn infants wh o had no gross abnormalities, and 5 mothers of stillborn infants with neural tube defects, CD1+, CD3+, CD4+, and CD8+ cells were studied, On ly the mothers of the infants with open neural tube defects showed CD1 + cells in their peripheral blood. (C) 1995 Wiley-Liss, Inc.