SIMULTANEOUS CISPLATIN AND RADIATION IN ENDOMETRIAL ADENOCARCINOMA CELL-LINES

The effects of concomitantly administered cisplatin and radiation were evaluated in four recently established endometrial adenocarcinoma cel l lines. We used the 96-well clonogenic assay to obtain survival data which were fitted to the linear quadratic model. The area under the su rvival curve (AUG) was obtained by numerical integration. It turned ou t that there was only a systematic additive cytotoxic effect and no su pra-additive, true radiosensitising effect could be found. The results were not affected by the cisplatin dose used, the intrinsic radiosens itivity of the cell lines or the sensitivity of the cells to cisplatin .