Ac. Mathur et al., INFLUENCE OF SUBCLINICAL NEMATODOSIS ON THE KINETIC DISPOSITION OF FENBENDAZOLE IN BUFFALOS, Veterinary research communications, 19(1), 1995, pp. 49-57
The disposition kinetics of fenbendazole was studied in buffaloes subc
linically infected with gastrointestinal nematodes. There was signific
antly reduced uptake of the drug in infected animals compared to uninf
ected controls. The pH of the duodenal liquor was highly alkaline comp
ared to the acidic pH in uninfected animals. The egg count in the faec
es never became zero though the numbers were reduced to a great extent
compared to pre-treatment values. The influence of the host's physiol
ogy on the reduced bioavailability of fenbendazole is discussed.