EFFICACY OF AMBISOME IN MURINE COCCIDIOIDOMYCOSIS

Authors
ALBERT MM ADAMS K LUTHER MJ SUN SH GRAYBILL JR
Citation
Mm. Albert et al., EFFICACY OF AMBISOME IN MURINE COCCIDIOIDOMYCOSIS, Journal of medical and veterinary mycology, 32(6), 1994, pp. 467-471
Citations number
23
Categorie Soggetti
Mycology
Journal title
Journal of medical and veterinary mycology → ACNP
ISSN journal
02681218
Volume
32
Issue
6
Year of publication
1994
Pages
467 - 471
Database
ISI
SICI code
0268-1218(1994)32:6<467:EOAIMC>2.0.ZU;2-6
Abstract
ICR mice were infected intranasally with arthroconidia of Coccicioides immitis. Mice were treated intravenously with amphotericin B deoxycho late (Fungizone) or an amphotericin B-lipid vehicle (AmBisome). Doses ranged from 0.05 to 1.0 mg kg(-1). Lung weight, which parallels diseas e severity and fungal burden in this infection, was used as the index of protection. Both Fungizone and AmBisome were significantly and equa lly protective at 0.3 and 1.0 mg kg(-1) body weight.