RENAL GLOMERULAR FIBROSIS IN A CAT

Renal glomerular fibrosis was observed in a 1-year-old spayed female J apanese domestic cat that showed clinically advanced renal failure. In the glomeruli, increased homogeneous materials were stained strongly with aniline blue by Masson's trichrome and positive for anti-type III collagen antibody by immunohistochemical staining, causing mesangial sclerosis and capillary collapse. By electron microscopy, randomly arr anged fibrils were observed in the expanded subendothelial and mesangi al areas, and the fibrils showed periodicity characteristic of collage n fibers in longitudinal sections. These findings of glomerular lesion s closely resemble those of human ''collagenofibrotic glomerulonephrop athy,'' which has recently been described as a new type of glomerulone phropathy.