CONGENITAL CYSTIC-DISEASE OF THE LIVER, PANCREAS, AND KIDNEY IN A NUBIAN GOAT (CAPRA-HIRCUS)

A congenital cystic disease of the liver, pancreas, and kidney was dia gnosed in a 3-week-old female Nubian goat (Capra hircus). Gross and hi stologic features were similar to autosomal recessive polycystic kidne y disease in humans and to previous reports of juvenile polycystic dis orders in several animal species. Grossly, the lesions were confined t o the liver and pancreas. The liver was severely enlarged and containe d multiple fluid-filled cysts of various sizes. There was tortuous ect asia of the extrahepatic bile ducts. In the pancreas, multiple small c ysts were disseminated throughout the parenchyma. Histologically, ther e was cavernous ectasia of the intra- and extrahepatic biliary system. Dilated intrahepatic biliary channels formed a branching and anastomo sing pattern throughout the hepatic parenchyma and were often bordered by fibrous connective tissue. The pancreas had dilation of intra- and interlobular ducts. Renal cortical tubules and collecting ducts were ectatic. Congenital polycystic disorder has not been documented previo usly in the goat.