CORRELATION OF BIOCONCENTRATION FACTOR WI TH PARTITION-COEFFICIENT OFBENZENE-DERIVATIVES IN AQUEOUS 2-PHASE SYSTEM

The partition coefficients of eight kinds of benzene derivatives, whic h are well-known toxic compounds, were measured in the aqueous two-pha se systems containing polyethylene glycol(($) over bar M(W)=7,500) and dipotassium hydrogenphosphate at 298.15 K. Results of correlation of bioconcentration factors with the partition coefficients measured in t he aqueous two-phase system were compared with these obtained from the literature data which were determined in the octanol-water partition system for the benzene derivatives. It was found that the partition co efficients of benzene derivatives measured in the aqueous two-phase sy stem could give a better correlation with the bioconcentration factors .