IMMUNOTHERAPY BY BCG AGAINST PROSTATE ADENOCARCINOMAS IN ANATOMICAL COMPARTMENTS

The prostate adenocarcinoma-lll (PA-III) cell line manifests a high ra te of metastasis from the SC tumor site through lymphatic channeis to the lungs in which they produce visible focal tumors. IV inoculation o f BCG interfered with the passage of PA-III cells to the lungs; but no t if the BCG was inoculated IF. IP inoculation of BCG suppressed propa gation of PA-III cells in the peritoneal cavity, but there was no effe ct on metastasis of PA-III cells from a SC PA-III tumor to the lungs. Inoculation of BCG did not induce a systemic anticancer effect unless PA-III cells and BCG occupied the same anatomical compartment. Two com partments are described:intravascular and intraperitoneal.