P53-MEDIATED CELLULAR-RESPONSE TO DNA-DAMAGE IN CELLS WITH REPLICATIVE HEPATITIS-B VIRUS

Authors
PUISIEUX A JI JW GUILLOT G LEGROS Y SOUSSI T ISSELBACHER K OZTURK M
Citation
A. Puisieux et al., P53-MEDIATED CELLULAR-RESPONSE TO DNA-DAMAGE IN CELLS WITH REPLICATIVE HEPATITIS-B VIRUS, Proceedings of the National Academy of Sciences of the United Statesof America, 92(5), 1995, pp. 1342-1346
Citations number
48
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
92
Issue
5
Year of publication
1995
Pages
1342 - 1346
Database
ISI
SICI code
0027-8424(1995)92:5<1342:PCTDIC>2.0.ZU;2-Z
Abstract
Wild-type p53 acts as a tumor suppressor gene by protecting cells from deleterious effects of genotoxic agents through the induction of a G( 1)/S arrest or apoptosis as a response to DNA damage. Transforming pro teins of several oncogenic DNA viruses inactivate tumor suppressor act ivity of p53 by blocking this cellular response. To test whether hepat itis B virus displays a similar effect, we studied the p53-mediated ce llular response to DNA damage in 2215 hepatoma cells with replicative hepatitis B virus. We demonstrate that hepatitis B virus replication d oes not interfere with known cellular functions of p53 protein.