EVOLUTION OF AFTERDISCHARGE AND SEIZURE CHARACTERISTICS DURING ELECTRICAL KINDLING OF THE GUINEA-PIG

Interspecies comparisons may help us understand the mechanisms which u nderlie brain plasticity. In this study, we examined the electrical ki ndling phenomenon in the amygdala, piriform and perirhinal regions of the guinea-pig. The changes in afterdischarge (AD) characteristics and behavioural seizures were assessed under different stimulation interv als and parameters as well as under reduced inhibitory neurotransmitte r systems. We report that the guinea-pigs displayed a number of simila rities with other species, such as the progressive increases in AD cha racteristics and seizure behaviours, but also a number of differences, such as the behavioural manifestations of the seizures, failing to re ach a fully generalized tonic-clonic seizure and an apparent insensiti vity to both low-frequency stimulation and reduced GABA and catecholam ine levels.