RAPID PROGRESSION TO DISEASE IN AFRICAN SEX WORKERS WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION

From a cohort of female sex workers in Nairobi, Kenya, 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-1-related disease. The effec t of several covariables on disease progression was studied using a We ibull proportional hazards model. The Weibull survival model was fitte d to the observed incubation times. Estimates of the median duration t o CDC stage IV-A and IV-C disease were 3.5 and 4.4 years, respectively . Condom use before seroconversion was associated with a reduced risk of CDC stage IV-A disease (relative risk = .64, P < .05). The incubati on time of HIV-1-related disease is extremely short in this population .