HYPOTENSIVE CONSTITUENTS FROM THE BARK OF HOLARRHENA-PUBESCENS (HOLARRHENA-ANTIDYSENTERICA)

Authors
SIDDIQUI BS USMANI SB BEGUM S SIDDIQUI S AFTAB K GILANI AUH
Citation
Bs. Siddiqui et al., HYPOTENSIVE CONSTITUENTS FROM THE BARK OF HOLARRHENA-PUBESCENS (HOLARRHENA-ANTIDYSENTERICA), Heterocycles, 41(2), 1995, pp. 267-276
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
41
Issue
2
Year of publication
1995
Pages
267 - 276
Database
ISI
SICI code
0385-5414(1995)41:2<267:HCFTBO>2.0.ZU;2-8
Abstract
Two new alkaloids of conanine series, holamide (N-(N'-methylacetamido) 3-oxo-1,4-conadiene) (1), pubescinine (11 alpha-acetoxy-N-demethyl-3-o xo-1,4,17 (20)-conatriene) (2) and a known alkaloid norconessine (3-N- methylamino-5-conanene) (3), have been isolated from the bark of Holar rhena pubescens Buch. Ham (Holarrhena antidysenterica Linn.) (Apocynac ea). Their structures have been established through spectroscopic stud ies. Both 1 and 2 showed hypotensive activity in rats at a dose of 3 m g/kg.