SOLUBLE TUMOR-NECROSIS-FACTOR RECEPTOR RELEASE AFTER ANTI-CD3 MONOCLONAL-ANTIBODY TREATMENT IN MICE IS INDEPENDENT OF TUMOR-NECROSIS-FACTOR-ALPHA RELEASE

Authors
VOSSEN ACTM TIBBE GJM BUURMAN WA BENNER R SAVELKOUL HFJ
Citation
Actm. Vossen et al., SOLUBLE TUMOR-NECROSIS-FACTOR RECEPTOR RELEASE AFTER ANTI-CD3 MONOCLONAL-ANTIBODY TREATMENT IN MICE IS INDEPENDENT OF TUMOR-NECROSIS-FACTOR-ALPHA RELEASE, European cytokine network, 7(4), 1996, pp. 751-755
Citations number
34
Categorie Soggetti
Cell Biology
Journal title
European cytokine network → ACNP
ISSN journal
11485493
Volume
7
Issue
4
Year of publication
1996
Pages
751 - 755
Database
ISI
SICI code
1148-5493(1996)7:4<751:STRRAA>2.0.ZU;2-#
Abstract
The involvement of TNF-alpha in the release of soluble TNF receptors w as assessed in mice, treated with anti-CD3 monoclonal antibodies. Afte r treatment with three different anti-CD3 mAb, we simultaneously studi ed serum levels of TNF-alpha soluble TNF receptor P55 and P75, All thr ee anti-CD3 mAb triggered the release of both of the soluble TNF recep tors, whereas only one of the anti-CD3 mAb triggered TNF-alpha release . These data demonstrate that in our model soluble TNF receptor releas e is independent of TNF-alpha release.