SERUM INTERLEUKIN-10 IN ACQUIRED-IMMUNODEFICIENCY-SYNDROME LYMPHOMA PATIENTS

Authors
EDELMAN L DEVEAU C RAPHAEL M MONCHATRE E GABARRE J DEVILLECHABROL A PIALOUX G EMILIE D JOAB I GALANAUD P ROUZIOUX C BARY M BURGARD M GALLAIS H MARS ME GALLAIS J DELLAMONICA P PERBOST I CARLES M CASSUTO JP REBOULOT B QUARANTA M LEFRERE JJ LERABLE J JOUBERT L DUPONT B BEUZELIN C FOURNIER S DORMONT J DELFRAISSY JF LEVY A BOUE F VITTECOQ D BOLLIOT C PECHALAT MT LEBRAS P GOUJARD C QUERTAINMONT Y GASTAUT JA DHIVER C DROGOUL MP GAZENGEL C PERTUISSET N ROTSCHILD M HERSON S COUTELLIER A SERENI D GOMEZ V BACHMEYER C VILDE JL LEPORT C COLASSANTE U PEYNET J LAUX C KATLAMA C BRUCKER G LAURIAN Y KEBEDJI L LAMBERT T SOBEL A DUVAL J MAJERHOLE C DEFORGES L KAZATCHKINE M VELLAY A BUISSON M SULTAN Y GAUTREAU C PICARD F GUILLEVIN L LAROUSSE B TROGOFF B
Citation
L. Edelman et al., SERUM INTERLEUKIN-10 IN ACQUIRED-IMMUNODEFICIENCY-SYNDROME LYMPHOMA PATIENTS, European cytokine network, 7(4), 1996, pp. 785-791
Citations number
27
Categorie Soggetti
Cell Biology
Journal title
European cytokine network → ACNP
ISSN journal
11485493
Volume
7
Issue
4
Year of publication
1996
Pages
785 - 791
Database
ISI
SICI code
1148-5493(1996)7:4<785:SIIALP>2.0.ZU;2-N
Abstract
Interleukin-10 (IL-10) has multiple effects on lymphoid development, p articularly as a stimulant of activated B-cell proliferation and diffe rentiation. It is thought that IL-10 might play a role in the developm ent of B lymphoid malignancies based on the observation that lymphomat ous tissues from HIV+ patients contain numerous cells containing IL-10 mRNA as well as IL-10 protein. The aim of this study using an Elisa t est was to analyze IL-10 in the serum of 18 HIV+ patients with non Hod gkin's B lymphoma (NHL) and compared the presence of this cytokine in the serum of 18 HIV+ patients without NHL. In this comparitive study w e also considered the different parameters such as the mode of contami nation, sex, age and number of CD4 cells. 44% of the patients with HIV -related NHL had significant levels of IL-10 (greater than or equal to 12 pg/ml) in their serum, in comparison to the patients without NHL w ho did not show detectable serum IL-10.