CHEMILUMINESCENCE DETERMINATION OF SOME LOCAL-ANESTHETICS

The analytical possibilities of the chemiluminescence observed from so me local anaesthetics on acidic permanganate treatment are investigate d. Five drugs belonging to the p-aminobenzoate series gave significant emission and the reagent concentrations for their determination were optimized. The following detection limits were obtained: benzocaine, 3 0 ng ml(-1); butacaine, 20 ng ml(-1); butoform, 30 ng ml(-1); procaine , 40 ng ml(-1) and tetracaine 3 ng ml(-1). The application of the reac tion to the analysis of some pharmaceutical preparations containing be nzocaine and procaine was evaluated.