Depressive disorders are far more serious than most people realize, an
d depressive disorders are disabling affected persons progressively ea
rlier in life. Heavy utilization of medical services, extensive disabi
lity and morbidity, and high suicide risk exact a staggering economic
toll in the United States annually. Depressive illness is, like pneumo
nia and septic shock, a dread complication of major medical illness, a
nd depressive illness appears more frequently as the medical illness w
orsens; diseases affecting the brain may have the highest rates of dep
ressive symptoms. Correctly diagnosing a depressive disorder in a medi
cally ill patient is a clinical challenge that requires systematic, pe
rsistent clinical scrutiny. Compassion demands that depressive disorde
rs, when diagnosed, be treated aggressively.