PROSTAGLANDIN G H SYNTHASE-1 MESSENGER-RNA RELATIVE ABUNDANCE IN HUMAN AMNION, CHORIODECIDUA AND PLACENTA BEFORE, DURING AND AFTER SPONTANEOUS ONSET LABOR AT TERM/

The aim of this study was to determine the relative abundance of prost aglandin G/H synthase-1 (PGHS-1) mRNA in human amnion, choriodecidua a nd placenta obtained before (n = 5), during (n = 5) and after spontane ous-onset labour and delivery at term (n = 5). PGHS-1 mRNA relative ab undance was not affected by labour status (p > 0.1) nor differently ex pressed between gestational tissues (p > 0.05). These data are consist ent with the hypothesis that PGHS-1 is a constitutively expressed isoz yme and that an increase in the relative abundance of mRNA encoding th is enzyme is not necessary for the labour-associated increase in prost aglandin formation.