TISSUE-PLASMINOGEN ACTIVATOR AND PLASMINOGEN-ACTIVATOR INHIBITORS OF TYPE-1 AND TYPE-2 IN AMNIOTIC-FLUID BEFORE LABOR AND AFTER CHILDBIRTH

We measured three selected components of the fibrinolytic system in am niotic fluid of 36 parturient women, i.e. the antigen of tissue plasmi nogen activator (tPA) and antigens of plasminogen activator inhibitor of type 1 (PAI-1) and type 2 (PAI-2). The ELISA method was used. Durin g labour, the level of each of the studied antigens increases; tPA ant igen increases over five times (0.91 +/- 0.32 ng/ml before labour and 5.92 +/- 1.83 ng/ml after childbirth), which is statistically signific ant, while at the same time the increase in PAI-1 and PAI-2 antigen le vels is small and thus statistically insignificant. As the result of u nequal changes, the prelabour dominance of PAIs over tPA decreases int ra partum (tPA/PAIs ratio 1:1,038 before labour and 1:164 after childb irth), and yet the multiple dominance of PAIs over tPA remains.