BLOOD-COAGULATION AND FIBRINOLYSIS IN ECLAMPTIC PATIENTS AND THEIR CORRELATION WITH THE CLINICAL SIGNS

We studied the impact of blood coagulation and fibrinolysis on the cli nical features of eclamptic patients (n = 20) in Bangladesh. The varia bles used were edema, proteinuria, blood pressure, number of convulsio ns, level of consciousness at the time of admission, thrombin antithro mbin complexes (TAT), antithrombin (AT) III (%) activity and antigen, D dimer fibrin degradation product and alpha(2)-plasmin inhibitor-plas min complex (PIC) in plasma. Canonical correlation analysis was made t o obtain clinical index, eclampsia index and two coagulation indices. On admission, the mean values of coagulation parameters were AT III ac tivity: 83.2% (range 57-108), TAT complex: 47.6 ng/ml (range 11.5-60), D dimer: 1,693 ng/ml (range 417-8,276) and PIC 1.4 mg/ml (range 0.4-3 .3). We found a significant correlation between the eclampsia index an d clinical index (r = 0.601; p = 0.01). Gestosis index, clinical index , and eclampsia index have also a strong correlation with the coagulat ion index (r = 0.695, p < 0.005; r = 0.871, p < 0.0001 and r = 0.805, p < 0.0001, respectively). Coagulation and fibrinolysis were markedly activated in eclampsia. The correlation between the clinical status an d coagulation status in this study suggested a close relation between the coagulation and the development and progression of the disease.