CALBINDIN-D28K LOCALIZATION IN THE PRIMATE INNER-EAR

Citation
S. Usami et al., CALBINDIN-D28K LOCALIZATION IN THE PRIMATE INNER-EAR, ORL, 57(2), 1995, pp. 94-99
Citations number
NO
Categorie Soggetti
Otorhinolaryngology
Journal title
ORLACNP
ISSN journal
03011569
Volume
57
Issue
2
Year of publication
1995
Pages
94 - 99
Database
ISI
SICI code
0301-1569(1995)57:2<94:CLITPI>2.0.ZU;2-E
Abstract
The distribution of one of the calcium-binding proteins, calbindin-D28 K (CB-D28K), was studied in the adult human and squirrel monkey inner ear by means of immunocytochemical methods. Inner and outer hair cells in the organ of Corti and vestibular hair cells showed CB-D28K immuno reactivity, though some vestibular hair cells were devoid of immunorea ctivity. In the spiral and vestibular ganglion, immunoreactive cells w ere found in both the squirrel monkey and human. The present results i ndicate that CB-D28K is localized within afferent neuronal components in these sensory organs and may regulate Ca++ levels for optimal neuro transmission in the primate auditory and vestibular systems. This stud y also provides evidence of two nonneuronal localizations of CB-D28K i n the squirrel monkey. Subpopulations of fibrocytes in the spiral liga ment and vestibular end organs were enriched with CB-D28K, suggesting that these cells are possibly equipped with the function to regulate C a++ concentration in the perilymphatic fluid. In the maculae, many CB- D28K-immunoreactive particles were found in the otoconial membrane, in dicating that CB-D28K may participate in the formation of otoconia.