EPI IMAGING OF GLOBAL INCREASE OF BRAIN MR SIGNAL WITH BREATH-HOLD PRECEDED BY BREATHING O-2

Authors
KWONG KK WANKE I DONAHUE KM DAVIS TL ROSEN BR
Citation
Kk. Kwong et al., EPI IMAGING OF GLOBAL INCREASE OF BRAIN MR SIGNAL WITH BREATH-HOLD PRECEDED BY BREATHING O-2, Magnetic resonance in medicine, 33(3), 1995, pp. 448-452
Citations number
17
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Magnetic resonance in medicine → ACNP
ISSN journal
07403194
Volume
33
Issue
3
Year of publication
1995
Pages
448 - 452
Database
ISI
SICI code
0740-3194(1995)33:3<448:EIOGIO>2.0.ZU;2-B
Abstract
Brain MR signal has been observed to decrease during cessation of brea thing due to the increase of deoxyhemoglobin in the blood. However, fo r both animal and human studies, we have demonstrated that if the subj ects breathed 100% oxygen in advance of apnea for a short time, T-2-w eighted MR brain signal increased when breathing was stopped for a per iod of 30-60 s. This demonstrates the possibility of measuring respons es to hemodynamic change throughout the entire brain with a single res piratory perturbation in a rapid, reliable, and robust manner.