USEFULNESS OF GRANULOCYTE-COLONY-STIMULATING FACTOR ON NEUTROPENIA INPATIENTS OF INVASIVE MOLE AND CHORIOCARCINOMA

The effect of human granulocyte colony stimulating factor (hG-CSF) was investigated on the proliferation of choriocarcinoma cells in vitro. No growth stimulating effect was observed. Then, 22 patients with inva sive mole and 9 patients with choriocarcinoma who received combination chemotherapy were treated with hG-CSF when white blood cell counts de creased below 2,000/mm(3). The duration of neutropenia was reduced sig nificantly by 3-4 days with the use of hG-CSF. No side effects were ob served. These results indicate safety and usefulness of hG-CSF as an a djunct to chemotherapy in the treatment of gestational trophoblastic d isease.