PROLONGED BLEEDING-TIME DURING CIPROFLOXACIN THERAPY

Ciprofloxacin is a broad spectum quinolone antibiotic. Side effects re ported include nausea and other gastrointestinal symptoms; skin and mu sculoskeletal side effects may also occur. No bleeding abnormalities o r alteration in coagulation have been documented. We report a case whe re ciprofloxacin appeared to contribute to an idiosyncratic prolongati on of bleeding time although a rechallenge 8 months later did not repr oduce the effect. Moreover, subsequent investigation of the influence of ciprofloxacin on bleeding parameters in 10 healthy volunteers demon strated no alterations in bleeding parameters.